Selected Publications

  • Ganglioside GM1 and the Central Nervous System. (Review) Zhongwu Guo* Int. J. Mol. Sci. 2023, 24, 9558.
  • Glycosphingolipid and Glycosylphosphatidylinositol Affect Each Other in and on the Cell (Review) Zhongwu Guo* ChemBioChem 2023, e202200761.
  • Diversity-Oriented Synthesis of Glycosylphosphatidylinositol Probes Based on an Orthogonally Protected Pentasaccharide. Xin Yan and Zhongwu Guo* Org. Lett. 2023, https://doi.org/10.1021/acs.orglett.3c00448.
  • Development in the Concept of Bacterial Polysaccharide Repeating Unit-Based Antibacterial Conjugate Vaccines. Rajendra Rohokale and Zhongwu Guo* ACS Infect. Dis. 2023, 2023, 9, 2, 178–212. https://doi.org/10.1021/acsinfecdis.2c00559
  • Profiling Glycosylphosphatidylinositol (GPI)-Interacting Proteins in the Cell Membrane Using a Bifunctional GPI Analogue as the Probe. Sayan Kundu, Chuwei Lin, Mohit Jaiswal, Venkanna Babu Mullapudi, Kendall C. Craig, Sixue Chen, and Zhongwu Guo* J. Proteome Res. 2023,
  • Labeling cell surface glycosylphosphatidylinositol-anchored proteins through metabolic engineering using an azide-modified phosphatidylinositol. Sayan Kundu, MohitJaiswal, Kendall C.Craig, JiatongGuo, ZhongwuGuo* Biochemical and Biophysical Research Communications, 2023, 645, 103-109.
  • Synthesis of a Bifunctionalized Glycosylphosphatidylinositol (GPI) Anchor Useful for the Study of GPI Biology. Venkanna Babu Mullapudi, Kendall C. Craig and Zhongwu Guo* Chemistry – A European Journal. 2022, 10.1002/chem.202203457.
  • Design and Synthesis of a Doubly Functionalized Core Structure of a Glycosylphosphatidylinositol Anchor Containing Photoreactive and Clickable Functional Groups. Venkanna Babu Mullapudi, Kendall C. Craig and Zhongwu Guo* J. Org. Chem. 2022, 87, 14, 9419–9425.
  • The structural diversity of natural glycosphingolipids (GSLs). Zhongwu Guo* Journal of Carbohydrate Chemistry, 2022, 41:2-3, 63-154.
  • Design and synthesis of 4-azido-phosphatidylinositol as a potential probe for metabolic engineering of glycosylphosphatidylinositol on cells. Kendall C. Craig and Zhongwu Guo* Journal of Carbohydrate Chemistry, 2022, 41:4, 238-248.
  • Structural characterization and analysis of different epimers of neutral glycosphingolipid LcGg4 by ion mobility spectrometry-mass spectrometry. Tianqi Gao, Aneirin A. Lott, Fanran Huang a, Rajendra Rohokale, Qingjiang Li, Hernando J. Olivos, Sixue Chen* and Zhongwu Guo* Analyst, 2022, 147, 3101-3108.
  • Enzymatic glycoengineering-based spin labelling of cell surface sialoglycans to enable their analysis by electron paramagnetic resonance (EPR) spectroscopy. Mohit Jaiswal, Trang T. Tran, Jiatong Guo, Mingwei Zhou, Josefina Garcia Diaz, Gail E. Fanucci* and Zhongwu Guo* Analyst, 2022, 147, 784
  • Synthesis of Structurally Defined Nitroxide Spin-Labeled Glycolipids as Useful Probes for Electron Paramagnetic Resonance (EPR) Spectroscopy Studies of Cell Surface Glycans. Xin Yan, Zhongwu Guo* Synthesis 2022; 54(12), 2856-2864.
  • Direct access to various C3-substituted sialyl glycal derivatives from 3-iodo-sialyl glycals. Qingjiang Li and Zhongwu Guo*Org. Biomol. Chem., 2021,19, 10169-10173
  • Analysis and Comparison of Mouse and Human Brain Gangliosides via Two-Stage Matching of MS/MS Spectra, https://doi.org/10.1021/acsomega.1c07070
  • Enzymatic Synthesis of Glycosphingolipids: A Review. Q. Li, and Z. Guo, Synthesis 2021, 53, A–N.
  • Characterization of Glycosphingolipids and Their Diverse Lipid Forms through Two-Stage Matching of LC-MS/MS Spectra.     L. S. Bailey, F. Huang, T. Gao, J. Zhao, K. B. Basso and Z. Guo, Anal. Chem. 2021, 93, 3154–3162.
  • A Diversity-Oriented Strategy for Chemical Synthesis of Glycosphingolipids: Synthesis of Glycosphingolipid LcGg4 and Its Analogues and Derivatives. R. S. Rohokale and Z. Guo, J. Org. Chem. 2021, 86, 1633–1648.
  • A Diversity-Oriented Strategy for Chemoenzymatic Synthesis of Glycosphingolipids and Related Derivatives. Q. Li, M. Jaiswal, R. S. Rohokale and Z. Guo, Org. Lett. 2020, 22, 8245–8249.
  • Metabolically Engineered Spin-Labeling Approach for Studying Glycans on Cells. M.  Jaiswal, T. T. Tran, Q. Li, X. Yan, M. Zhou, K. Kundu, G. E. Fanucci and Z. Guo, Chem. Sci., 2020, 11, 12522-12532.
  • Synthesis and evaluation of Nα,Nε-diacetyl-L-lysine-inositol conjugates as cancer-selective probes for metabolic engineering of GPIs and GPI-anchored proteins. M. Jaiswal, S, Zhu, W. Jiang, Z. Guo, Org. Biomol. Chem., 2020,18, 2938-2948.
  • Comparative immunological studies of tumor-associated Lewis X, Lewis Y, and KH-1 antigens. J. Guo, W. Jiang, J. Guo, Q. Li, M. Jaiswal andZ. Guo, Carbohydrate Research 2020, 492, 107999.
  • Synthesis of Lewis Y Analogs and Their Protein Conjugates for Structure-Immunogenicity Relationship Studies of Lewis Y Antigen. Q. Li, W. Jiang, J. Guo, M. Jaiswal, and Z. Guo, J. Org. Chem. 2019, 84, 21, 13232–13241.
  • An Investigation of the Reactions between Azido Alcohols and Phosphoramidites. J. Wu, L. Bishop, J. Guo and Z. Guo, Synlett 2019, 30, 348-352.
  • Recent Advances in Toll Like Receptor-Targeting Glycoconjugate Vaccines. Q. Li and Z. Guo, Molecules 2018, 23, 1583.
  • Progress in the synthesis and biological evaluation of lipid A and its derivatives. J. Gao and Z. Guo, Med Res Rev. 2018; 38, 556– 601.
  • Synthesis of the Cancer-Associated KH-1 Antigen by Block Assembly of Its Backbone Structure Followed by One-Step Grafting of Three Fucose Residues. Q. Li and Z. Guo, Org. Lett. 2017, 19, 6558–6561.
  • Pondering the structural factors that affect 1,2-trans-galactosylation: A lesson learnt from 3-O-β-galactosylation of galactosamine. Q. Li and Z. Guo, Journal of Carbohydrate Chemistry, 2017, 36, 347-362.
  • Synthesis and Evaluation of GM2-Monophosphoryl Lipid A Conjugate as a Fully Synthetic Self-Adjuvant Cancer Vaccine. Z. Zhou, S. S. Mandal, G. Liao, J. Guo and Z. Guo, Sci Rep, 2017, 7, 11403.
  • Chemical Synthesis of GPI Glycan–Peptide Conjugates by Traceless Staudinger Ligation. S. Zhu and Z. Guo, Org. Lett. 2017, 19, 3063–3066.
  • Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins. J. Gao, Z. Zhou, J. Guo and Z. Guo, Chem. Commun., 2017, 53, 6227-6230.
  • One-Pot Four-Enzyme Synthesis of dTDP-Rha. Li, H. Wang, J. Ma, G. Gu, Z. Chen and Zhongwu Guo, Chem. Commun., 2016, 52, 13995-13998.

        

  • Chemical Synthesis of the Repeating Unit of Type V GBS Capsular Polysaccharide, J. Gao and Z. Guo, Org. Lett., 2016, 18, 5552.

          

  • A Fully Synthetic Self-Adjuvant Conjugate Vaccine against Group C Meningitis,G. Liao, Z. Zhou, S. Suryawanshi, M. A. Mondal and Z. Guo, ACS Cent. Sci., 2016, 2, 210.

         

  • A New Branched ß-Glucan-Based Antifungal Conjugate Vaccine. Liao, Z. Zhou, J. Liao, L. Zu, Q. Wu, and Z. Guo, ACS Infect. Dis., 2016, 2, 123.

         

  • A Fully Synthetic Self-Adjuvanting Globo H-Based Vaccine Elicited Strong T Cell-Mediated Antitumor Immunity, Z. Zhou, G. Liao, S. S. Mandal, S. Suryawanshi, and Z. Guo, Chem. Sci., 2015, 6, 7112.

                

  • Cell Surface GPI Anchor Metabolic Engineering: A New Tool for the Study of Cell Surface GPI-Anchored Proteins, L. Lu, J. Gao, and Z. Guo, Angew. Chem. Int. Ed., 2015, 54, 9679.

         

  • Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins, R. Raghupathy, A. A. Anilkumar, A. Polley, P. P. Singh, M. Yadav, C. Johnson, S. Suryawanshi, V. Saikam, S. D. Sawant, A. Panda, Z. Guo, R. A. Vishwakarma, M. Rao, and S. Mayor, Cell, 2015, 161, 581.

                   

  • Chemical Synthesis of the Repeating Unit of Type Ia Group B Streptococcus Capsular Polysaccharide, P. K. Mondal, G. Liao, M. A. Mondal, Z. Guo, Org. Lett., 2015, 17, 1102.

     

  • A Novel Cancer Immunotherapy Based on the Combination of a Synthetic Carbohydrate-Pulsed Dendritic Cell Vaccine and Glycoengineered Cancer Cells, L. Qiu, J. Li, S. Yu, Q. Wang, Y. Li, Z. Hu, Q. Wu, Z. Guo, J. Zhang, Oncotarget, 2015, 6, 5195.

  • Synthesis and Immunological Studies of Linear Oligosaccharides of β-Glucan as Antigens for Anti-Fungal Vaccine Development, G. Liao, Z. Zhou, S. Burgula, J. Liao, C. Yuan, Q. Wu, and Z. Guo, Bioconjugate Chem., 2015, 26, 466.

           

  • Synthesis and Evaluation of Monophosphoryl Lipid A Derivatives as Fully Synthetic Self-Adjuvanting Glycoconjugate Cancer Vaccine Carriers, Z. Zhou, M. Mondal, G. Liao and Z. Guo, Org. Biomol. Chem., 2014, 12, 3238.

  • Synthesis of a Minature Lipoarabinomannan, J. Gao, G. Liao, L. Wang and Z. Guo, Org. Lett., 2014, 16, 988.

  • Sortase A-Mediated Chemoenzymatic Synthesis of Complex Glycosylphosphatidylinositol-Anchored Protein, Z. Wu, X. Guo, J. Gao, and Z. Guo, Chem. Commun., 2013, 49, 11689.

     

  •  Synthesis of a Tristearoyl Lipomannan via Pre-Activation-Based Iterative One-Pot Glycosylation, J. Gao and Z. Guo, J. Org. Chem., 2013, 78, 12717.

  •  Chemoenzymatic Synthesis of the Human CD52 and CD24 Antigen Analogs, Z. Wu, X. Guo, G. Gu, and Z. Guo, Org. Lett., 2013, 15, 5906.

  • A New Method for Site-Specific Modification of Liposomes with Proteins via Sortase A-Mediated Transpeptidation, Z. Wu, X. Guo, and Z. Guo, Bioconjugate Chem., 2012, 23, 650.

  •  Combining synthetic carbohydrate vaccines and cancer cell glycoengineering for effective cancer immunotherapy, L. Qiu, X. Gong, Q. Wang, J. Li, H. Hu, Q. Wu, J. Zhang, and Z. Guo, Cancer Immunol. Immunother., 2012, 61, 2045.

          

  • Carbohydrate-Monophosphoryl Lipid A Conjugates Are Fully Synthetic Self-Adjuvanting Cancer Vaccines Eliciting Robust Immune Responses in Mouse, Q. Wang, Zhifang Zhou, S. Tang and Z. Guo, ACS Chem. Biol., 2012, 7, 235.

  • Total Synthesis of a Glycosylphosphatidylinositol Anchor of the Human Lymphoctye CD52 Antigen, S. Burgula, B. M. Swarts and Z. Guo, Chem. Eur. J., 2012, 18, 1194.

  • Chemical Synthesis and Functionalization of Clickable Glycosylphosphatidylinositol Anchors, B. M. Swarts and Z. Guo, Chem. Sci., 2011, 2, 2342.

     

  • Sortase A-Catalyzed Peptide Cyclization for the Synthesis of Macrocyclic Peptides and Glycopeptides, Z. Wu, X. Guo and Z. Guo, Chem. Commun., 2011, 9218.

  • Synthesis of Glycosylphosphatidylinositol (GPI) Anchors Bearing Unsaturated Lipid Chains, B. M. Swarts and Z. Guo, J. Am. Chem. Soc., 2010, 132, 6648.

  • Sortase A-Catalyzed Transpeptidation of Glycosylphosphatidylinositol Derivatives for Chemoenzymatic Synthesis of GPI-Anchored Peptides/Proteins, Z. Wu, X. Guo, Q. Wang, B. M. Swarts, and Z. Guo, J. Am. Chem. Soc., 2010, 132,1567.

  • Sortase-Catalyzed Peptide-Glycosylphosphatidylinositol (GPI) Analog Ligation, X. Guo, Q. Wang, B. M. Swarts, and Z. Guo, J. Am. Chem. Soc., 2009, 131, 9878.

     

  • Synthesis and Antibacterial Activities of N-Glycosylated Derivatives of Tyrocidine A – a Macrocyclic Peptide Antibiotic, H. Hu, J. Xue, B. M. Swarts, Q. Wang, Q. Wu, and Z. Guo, J. Med. Chem., 2009, 52, 2052.

  • Synthetic and Immunological Studies of 5’N-phenylacetyl sTn to Develop Carbohydrate-Based Cancer Vaccines and to Explore the Impacts of Linkage between Carbohydrate Antigens and Carrier Proteins, Q. Wang, S. A. Ekanayaka, J. Wu, J. Zhang, and Z. Guo, Bioconjugate Chem., 2008, 19, 2060.

  • Synthesis and Biological Evaluation of Sperm CD52 GPI Anchor and Derivatives as Binding Receptors of the Pore-Forming Toxin – CAMP Factor, X. Wu, Z. Shen, X. Zeng, S. Lang, M. Palmer, and Z. Guo, Carbohydr. Res., 2008, 343, 1718.

       

  • A Total Synthesis of OSW-1, J. Xue, P. Liu, Y. Pan, and Z. Guo, J. Org. Chem., 2008, 73, 157.

  • Efficient Glycoengineering of GM3 on Melanoma Cell and Monoclonal Antibody-Mediated Selective Killing of the Glycoengineered Cancer Cell, Q. Wang, J. Zhang, and Z. Guo, Bioorg. Med. Chem., 2007, 15, 7561.

  • Biomimetic Glycoliposomes as Nanocarriers for Targeting P-Selectin on Activated Platelets, J. Zhu, J. Xue, Z. Guo, L. Zhang, and R. E. Marchant, Bioconjugate Chem., 2007, 18, 1366.

                

  • Effective Metabolic Engineering of GM3 on Tumor Cells by N-Phenylacetyl-D-mannosamine, P. Chefalo, Y. Pan, N. Nagy, C. Harding, and Z. Guo, Biochemistry, 2006, 45, 3733.

                

  • Cap and capture-release techniques applied to solid-phase oligosaccharide synthesis, J. Wu and Z. Guo, J. Org. Chem. 2006, 71, 7067.

  • Solution-Phase Synthesis with Solid-State Workup of an O-Glycopeptide with a Cluster of Cancer-Related T Antigens, N. Shao and Z. Guo, Org. Lett., 2005, 7, 3589.

  • Synthesis of a Lipid Conjugate of SO3Lea and Its Enhancement on Binding of Liposome to Activated Platelets, F. Yan, J. Xue, J. Zhu, R. Marchant, and Z. Guo, Bioconjugate Chem., 2005, 16, 90.

        

  • Synthesis and Immunological Properties of N-Modified GM3 as Therapeutic Cancer Vaccines, Y. Pan, P. Chefalo, N. Nagy, C. Harding, and Z. Guo, J. Med. Chem., 2005, 48, 875.

      

  • Chemical Synthesis of the Skeleton Structure of Sperm CD52 – A GPI-Anchored Glycopeptide, N. Shao, J. Xue, and Z. Guo, Angew. Chem. Int. Ed., 2004, 43, 1569.

  • Convergent Synthesis of a GPI Containing an Acylated Inositol, J. Xue and Z. Guo, J. Am. Chem. Soc., 2003, 125, 16334.

  • First Total Synthesis of a GPI-Anchored Peptide, J. Xue, N. Shao, and Z. Guo, J. Org. Chem., 2003, 68, 4020.

  • Efficient Synthesis of Complex Glycopeptides Based on Unprotected Oligosaccharides, J. Xue, and Z. Guo, J. Org. Chem., 2003, 68, 2713.

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  • Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins. Chem. Commun., 2017, 53, 6227-6230.